Sun X, Zhang D, Zhang W.
Effect of metformin on ovulation and reproductive outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials. Arch Gynecol Obstet. 2013 Aug;288(2):423-30.doi:10.1007/s00404-013-2756-5. Epub 2013 Feb 27.
PURPOSE:
To evaluate the effect of MET on ovulation and reproductive outcomes in patients with polycystic ovary syndrome.
METHODS:
Meta-analysis of available data from randomized controlled trials that examined the ovulation, pregnancy and live birth rate after the administration of clomiphene citrate (CC) or MET alone or combined.
RESULTS:
The ovulation rate was found to be higher in the group treated with MET combined with clomiphene citrate (CC) than only with CC, odds ratio (OR): 1.27, 95 % confidence interval (95 % CI) (1.03-1.56), while the pregnancy and live birth rate showed no significant difference between the two groups, OR: 1.19, 95 % CI (0.99-1.42) and OR: 0.99, 95 % CI (0.84-1.17), respectively. The MET + CC group produced a higher ovulation and pregnancy rate than MET group, OR: 2.10, 95 % CI (1.89-2.34) and OR: 2.08, 95 % CI (1.55-2.80), respectively, while between two groups the live birth rate showed no significant difference, OR: 1.50, 95 % CI (0.75-3.00). The ovulation rate was lower in MET than in CC group, OR: 0.65, 95 % CI (0.43-0.995), while between the two groups the pregnancy and live birth rate showed no significant difference, OR: 0.86, 95 % CI (0.42-1.74) and OR: 0.89, 95 % CI (0.71-1.13).
CONCLUSION:
The current study indicated that combination of MET and CC could gain advantage over a single administration in the ovulationinduction and pregnancy rate.